ADVANCING
HEALTH.
EXTENDING
LIFE.
IN AN AGE OF RAPIDLY ADVANCING KNOWLEDGE, SCIENCE AND AI, INCREASINGLY, WE CAN TREAT NOT ONLY WHAT HAS ALREADY HAPPENED, BUT ALSO PREVENT WHAT MIGHT HAPPEN.
DR SOPHIA KHALIQUE FOUNDER
I have been a doctor for over 36 years, and for more than two decades have worked as a private GP. During that time, medicine has changed profoundly, but what matters most has not.
Each clinical examination I undertake, begins the same way, listening, taking a careful history, examining thoughtfully, not just thoroughly. Investigating when needed, and ultimately, making decisions with a real, and always unique, person in front of me. An individual with their own goals, fears, responsibilities, and hopes for the future.
This experience has shaped how I think about health and healthcare. It has taught me that longevity is not an abstract concept, nor is it about chasing extremes. It is about preserving what allows people to live well – energy, clarity, strength, independence, and purpose.
Much of traditional medicine is principally reactive. We treat disease once symptoms appear, often when damage is already established. I have a passionate belief that the greatest opportunity lies earlier, in proactive and preventative care, and understanding how ageing itself influences health over time.
Advances in longevity medicine are allowing us to explore an individual’s health and ageing at unprecedented and ever-evolving depths; examples such as Genomics, where we can effectively read a body’s genetic instruction book, providing enhanced visibility and better insights into how we grow, function, and become unwell. AI biomarkers are providing us the ability to identify patterns in a patient’s medical data, offering earlier insights into disease risk and progression.
Cellular Health assessments, allow us to see how well a body’s fundamental building blocks are performing, and emerging therapies such as Senolytics, a class of drugs designed to remove worn, dysfunctional cells that impair healthy function. Epigenetic Insights further reveal how lifestyle and environment influence which genes are expressed or silenced over time. This growing field is helping identify new diagnostic and therapeutic targets, particularly in complex conditions such as cancer, neurodegenerative disease, and metabolic disorders.
sykle.life aims to bring these advances into accessible healthcare, grounded in research and evidence, guided by clinical judgement, and centred on the individual. We make no promises of immortality or dramatic transformation, only a commitment to honesty, rigour, and care.
My aim as a doctor has always been simple, to help people live lives that are not only longer, but healthier and more fulfilling, and to ensure scientific progress translates into something genuinely meaningful for those it serves.
WHAT DOES LONGEVITY HEALTHCARE REALLY MEAN?
At sykle.life, longevity healthcare is not simply about adding years alone. It is about preserving health, capability, and independence so that life remains active, engaged, and meaningful over time.
We combine extensive medical experience with leading-edge science and technologies to support both a longer lifespan and an optimised healthspan, the quality of how we live, move, think, and connect as we age.
Decades of clinical practice have reinforced one fundamental and unarguable truth – health is deeply personal.
Our focus is not on quick fixes or exaggerated claims, but on understanding the biology of ageing and slowing its impact responsibly.
Through this approach, we aim to support strength, cognitive clarity, resilience, and independence for as long as possible.
HOW CAN WE HELP?
Longevity means different things to different people. For some it is recovery, for others it’s prevention, vitality, or the ability to continue living life on their own terms.
At its core, longevity healthcare brings together essential foundations: Nutrition, Movement & Exercise, Sleep, Stress Management, and Family, Social & Environmental Connections, with carefully chosen scientific advances.
We embrace progress, not hype. Curiosity, not certainty. And medicine that serves the individual patient, not trends.
OUR COMMITMENT
In a world overwhelmed by health information, our role is to provide clarity. We focus on what the evidence shows, indicates or validates as proven and accredited fact. We explain the estimated timelines of what is emerging in the future and are transparent about what remains uncertain.
We do not promise outcomes we cannot support. Instead, we empower informed choice, helping people feel confident in their decisions and supported throughout their life journey.
THE SCIENCE OF AGEING
Ageing is something that happens to us all, but what actually causes our bodies to grow older and less efficient over time? Ageing is not the result of one single factor, but rather a mix of changes happening inside our cells and organs. Let’s take a look at some of the key players.
1. TELOMERES: THE PROTECTIVE CAPS
At the ends of our chromosomes are telomeres, which act like protective caps, stopping our DNA from getting tangled or damaged. Every time a cell divides, these caps get a little shorter. Eventually, they become too short, and the cell can no longer divide. Some special cells can rebuild their telomeres using an enzyme called telomerase, but most cannot—making telomere shortening one of the basic clocks of ageing.
2. SENESCENT CELLS: OLD AND STUBBORN
When cells get too old or too damaged, they stop dividing and turn into senescent cells. Think of them as “retired” cells that refuse to leave. Unfortunately, they aren’t harmless—they release substances that cause inflammation and damage nearby healthy cells. When we’re young, the immune system clears them out easily. But as we age, they start piling up, contributing to diseases like diabetes, cancer, and Alzheimer’s.
New treatments called senolytics are being tested to remove these harmful cells, while another type, senomorphics, aim to calm them down instead of killing them. Both approaches offer hope for slowing down age-related diseases.
3. MITOCHONDRIA: THE POWERHOUSES RUNNING LOW
Our cells are powered by tiny structures called mitochondria. Over time, they become less efficient, producing less energy and more harmful by-products. This leads to something called oxidative stress, where damage from free radicals overwhelms the body’s defences. This stress is a major driver of ageing and many related diseases.
4. INFLAMMATION: THE SILENT FIRE
As we get older, our bodies often experience chronic low-level inflammation—sometimes called “inflammaging.” Unlike the helpful kind of inflammation that heals wounds or fights infection, this lingering inflammation slowly wears down tissues and organs, raising the risk of heart disease, arthritis, and dementia.
5. PROTEINS: WHEN THINGS GO WRONG
Proteins are the workhorses of our cells, but with age they can get damaged or fold the wrong way. These broken proteins sometimes clump together, forming amyloids, which are linked to conditions like Alzheimer’s and Parkinson’s.
Normally, our cells use a cleaning process called autophagy to recycle damaged proteins, but this system weakens as we age, allowing toxic build-ups to occur.
6. EPIGENETICS: MORE THAN JUST DNA
Our genes don’t tell the whole story. Epigenetics looks at how lifestyle and environment—things like diet, stress, and pollution—can switch genes on or off without changing the DNA itself. These changes play a big role in how quickly or slowly we age, and why some people stay healthier for longer.
7. THE GUT: AN UNEXPECTED PLAYER
Recent research suggests the gut may be more important to ageing than we once thought. Changes in gut bacteria and a weakening gut barrier can let harmful substances leak into the bloodstream, sparking inflammation throughout the body. This “gut barrier theory” is an exciting new area of research into ageing.
PUTTING IT ALL TOGETHER
Ageing is not driven by a single factor but by a combination of interconnected processes—telomere shortening, cellular senescence, mitochondrial decline, inflammation, protein damage, epigenetic shifts, and changes in the gut microbiome.
As research progresses, strategies such as senolytic therapies, senomorphics, and interventions targeting oxidative stress and gut health hold promise for slowing biological ageing and extending healthy lifespan.
The Immortal Jellyfish is a species that can potentially live forever. It can transform its adult cells into juvenile cells. This process, called transdifferentiation, effectively resets its life cycle, theoretically enabling it to bypass death due to old age.
It starts life as a free-swimming larva, then settles on the seafloor and develops into a polyp. Once a jellyfish reaches adulthood, it reverts to the polyp stage, allowing it to restart its life cycle indefinitely.
PATHWAYS TO LONGEVITY
CARDIOVASCULAR RESILIENCE
Protecting the heart and blood vessels is central to living longer and healthier. Through advanced vascular optimisation and lipid management, we aim to reduce risk while preserving vitality.
REGENERATION & REPAIR
Our ability to heal and adapt declines with age. Regenerative strategies target tissue repair, musculoskeletal strength, recovery from injury, and the cellular signals that maintain resilience.
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of illness and death. By screening for key risk factors, we can intervene to slow or halt progression. Healthy circulation underpins every aspect of performance, healing, and regeneration — it is the machinery that powers you.
Our aim is to preserve your heart and blood vessels, so they serve you optimally for decades to come.
You recover and repair faster when your tissues rebuild well. With age, healing slows — niggles linger, tendons grumble, muscle takes longer to come back. We’ve seen athletes struggle not by injury itself but by the slower crawl back.
We pair precise diagnostics with doctor-guided regenerative strategies, so you spend more time on the pitch and less on the bench.
METABOLIC BALANCE
& ENERGY CONTROL
Maintaining metabolic stability supports weight, energy, and performance at every stage of life. We focus on optimising glucose control, insulin sensitivity, and cellular energy.
CELLULAR RENEWAL & LONGEVITY
Cutting-edge science is uncovering how cells age — and how we may influence the process. Cellular renewal strategies aim to support healthy ageing by modulating pathways linked to inflammation, repair, and resilience.
Metabolic health affects how efficiently your body manages energy production. Adverse changes in glucose handling, visceral fat, or insulin sensitivity can accelerate age-related decline.
We work to identify these patterns early and help restore balance, improve resilience, and keep your energy systems running smoothly. By combating weight gain, improving body composition, and improving health span.
Biological ageing begins deep within your cells. Senescent cells accumulate, mitochondria lose efficiency, and chronic inflammation spreads silently. We help you address these drivers, offering a precious chance to extend healthspan as well as lifespan.
Lifestyle shifts, senolytics and senomorphics — they’re all part of the quiet clean-up crew. Focusing on the cellular roots of ageing, we help you protect clarity of thought, physical stamina, and long-term independence.
NUTRITIONAL
& CELLULAR SUPERCHARGING
Longevity depends on the invisible architecture of nutrition and cellular metabolism. Precision supplementation strengthens the building blocks of cardiovascular, skeletal, and brain health.
LIFESTYLE & GENETICS
Genetic inheritance provides context, but lifestyle determines how your biology unfolds over time. We prioritise observable physiology, family history, and longitudinal health patterns to guide interventions that meaningfully influence healthspan. More detailed genetic insights can be investigated to refine understanding and guide better decision-making.
Cells are the building bricks of our body and cell function is key to bodily health. Subtle deficiencies can quietly erode performance and ageing processes result in changes that benefit from certain supplements.
Through testing and tailored supplementation, we help you strengthen your nutritional foundations and improve cellular metabolism thus helping sustain cellular function and protecting against premature ageing.
The interaction between your inherited biology and the pressures of modern life impact your health. Sleep disruption, chronic stress, nutrition, physical load, and recovery patterns all influence how genetic risk is expressed over time, often long before disease becomes visible.
We focus on aligning lifestyle factors with your individual biological tendencies, informed by your family history, physiology, and longitudinal patterns. Where appropriate, deeper genetic insight may be considered to refine understanding, Our emphasis remains on disciplined, evidence-led interventions that compound
Elephants rarely get cancer, even though they have 100 times more cells than humans, though statistically, they should be far more likely to develop it, their cancer rates are less than 5%, compared to 45% in humans (UK).
Their protection comes from extra copies of the TP53 tumour suppressor gene, which rapidly destroys damaged cells before they turn cancerous. Along with a reactivated “zombie gene” (LIF6) and highly efficient DNA repair, this gives elephants one of nature’s most powerful anti-cancer defences.
EVALUATION AND PROCESS
CLINICAL HISTORY
First you have structured pre-assessment questionnaire before your appointment. This includes details from your past medical and surgical history, current medications (including over-the-counter and supplements), allergies, and any current symptoms or concerns.
Lifestyle information is also collected—covering sleep, nutrition, exercise, alcohol, smoking, and other relevant exposures—to help contextualise risk.
Family history is reviewed in detail, with a focus on cardiovascular disease, cancer, metabolic conditions, and neurodegenerative disorders, to help identify inherited or shared risk factors. Finally, we ask about your personal health goals.
EXAMINATION
A detailed in-person physical examination is carried out by one of our experienced clinicians. This includes assessment of height, weight, body mass index (BMI), and waist circumference.
We record blood pressure and heart rate, and carry out a general systems examination covering cardiovascular, respiratory, abdominal, neurological and musculoskeletal
systems, tailored to your age, risk factors, and any reported symptoms. Urinalysis is performed to check for the presence of protein, glucose, blood, or signs of infection.
ELECTROCARDIOGRAM (ECG)
A resting electrocardiogram to screen for heart disease including silent ischaemia, rhythm and conduction disorders and strain on the heart muscles.
LUNG FUNCTION TEST
Spirometry to assess your respiratory health, measuring key parameters to assess baseline lung function and screen for decline which may occur with age, environmental exposure, or undiagnosed respiratory conditions.
HAND GRIP STRENGTH TESTING
Grip strength is assessed using a calibrated dynamometer. This simple, non-invasive test is an evidence-based marker of biological ageing and is strongly associated with healthspan and lifespan.
VO2 MAX TESTING
This is a gold-standard assessment of cardiorespiratory fitness. Quantifying the maximum amount of oxygen your body can use during exercise, it is a strong independent predictor of cardiovascular health, metabolic efficiency, and all-cause mortality. Results are interpreted against age- and sex-matched reference data, with individualised feedback on training zones.
BLOOD TESTING
A comprehensive panel of blood tests to assess key biomarkers of general health, and age-related disease risk. These include: Full blood count and haematology – _to detect anaemia, infection, clotting disorders, or abnormal cell lines.
- Liver and Kidney Function
To assess detoxification, metabolism, and filtration capacity. - Glucose and Insulin Markers
Including fasting glucose, fasting insulin, HbA1c, and HOMA-IR, to assess metabolic health, insulin resistance and diabetes risk. - Lipid and Cardiovascular Risk Profile
Including cholesterol subtypes, Apolipoprotein B, Lipoprotein(a), Lp-PLA2 (PLAC) blood test and high-sensitivity CRP. - Vitamin and Mineral Levels
Including Vitamin D, B12, folate, magnesium, calcium, phosphate, iron studies, and zinc. - Hormonal Profile
With measurement of cortisol, DHEA, IGF-1, oestrogen, testosterone, SHBG, LH, and FSH. - Inflammatory Markers
Including ESR and hs-CRP - Tumour Markers
CEA, CA125, CA19-9 and PSA (for men).
ADVANCED DIAGNOSTIC IMAGING
Advanced Diagnostic Imaging
Provide additional insights into structural health, vascular integrity, and early disease processes not detectable through other investigations. These studies are arranged selectively, guided by risk factors and clinical judgement, and are offered as optional enhancements to the core assessments.CT Lung Scan
A CT scan of the lungs to identify small pulmonary nodules or early changes not visible on standard chest X-ray. This may assist in the early detection of lung cancer or pre-cancerous changes, as well as evidence of chronic lung disease or prior injury.Carotid Doppler Ultrasound
A non-invasive ultrasound assessment of the carotid arteries to identify atherosclerotic plaque and vascular narrowing. Carotid disease is a recognised marker of systemic cardiovascular risk and may inform stroke prevention strategies.CT Coronary Calcium Scan
A gold-standard assessment of coronary artery calcification, providing a quantitative measure of atherosclerotic burden. This scan offers valuable long-term cardiovascular risk stratification, particularly in individuals without symptoms.CT Coronary Angiography (CTCA)
CT coronary angiography allows visualisation of coronary arteries, plaque, and any narrowing that may impair blood flow. This can be performed alongside a coronary calcium scan.Bone Mineral Density (DEXA) Scan
A low-dose X-ray assessment of bone density to evaluate skeletal strength and fracture risk. This investigation assists in the early identification of osteoporosis or accelerated bone loss.Mammography
A breast imaging study designed to detect early signs of breast cancer, often before clinical changes become apparent. Mammography remains an important tool in risk-based breast health assessment.MRI & MRA Brain Scan
Magnetic resonance imaging of the brain and cerebral blood vessels to identify structural or vascular abnormalities. This may detect early cerebrovascular disease, tumours, aneurysms, or other conditions associated with cognitive decline or neurological risk.Thyroid Ultrasound
An ultrasound assessment of the thyroid gland to evaluate nodules or structural abnormalities, including those that may warrant further investigation.Abdominal MRI Scan
High-resolution imaging of abdominal organs, including the liver, kidneys, pancreas, adrenal glands, spleen, and gall bladder. This scan may identify structural disease or early malignancy, including cancers that often remain clinically silent until advanced stages.Prostate Multiparametric MRI (mpMRI)
Gold-standard for prostate assessment using multiple imaging sequences to improve detection and characterisation of clinically significant prostate cancer, beyond the capabilities of standard MRI.Testicular Ultrasound
A focused ultrasound examination of the testes, typically considered in younger men where there are symptoms, examination concerns, or relevant risk factors.
FOLLOW UP CONSULTATION
Within 7 days, you will receive your personalised report and consultation with your doctor for an in-depth review.
This is where testing becomes a plan: clear, practical steps to protect health, improve performance, and extend vitality. Our recommendations draw on both established preventive medicine and carefully selected innovations in the science of ageing.
Axolotls are renowned for their exceptional regenerative capacity and negligible senescence. They exhibit sustained physiological function, resistance to age-related decline, and remarkable longevity.
Studies indicate that their epigenetic ageing clock effectively ceases around four years of age. Through neoteny, Axolotls retain their larval morphology into adulthood, maintaining the ability to regenerate complex tissues—including limbs, tail, and internal organs—without observable loss of regenerative efficiency over time.
FAQs
FEES AND MEMBERSHIP
| Initial Assessment and Appraisal: | £500 |
| Blood Tests: | £700 |
| Quarterly Review: | £250 |
Costs exclude Medications and Supplements which are subject to individual results.
Annual Membership is available at £12,000, charged monthly at £1,000. Membership includes Initial Assessment and Appraisal, Blood Tests, Quarterly Reviews, Vitamins, Supplements and Oral Medications
WHAT DO I DO IF I AM NOT HAPPY?
We value your feedback; good or bad, so please let us know. We carry out and publish annual patient satisfaction surveys. We are registered with The Care Quality Commission that regulates health and social care throughout England. We also have a formal complaints procedure if things have gone really badly and this can be accessed by contacting the Practice Manager
CARE QUALITY COMMISSION
The practice is registered with the Care Quality Commission, CRT1-12739950261, an executive non-departmental public body of the Department of Health and Social Care, responsible for the regulation and inspection of health and social care services in England.
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ENQUIRIES & CONSULTATIONS
For more information about our services or to arrange a consultation, please complete the form below or contact us directly at office@sykle.life or +44 020 3725 0800.